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08-Aug-2017 05:15

It is a disease where the body's immune system attacks the cells that make insulin.

Insulin helps sugar (glucose) get into your cells so it can be used as energy.

Our studies illustrate how islet transcription factors interact functionally with the epigenome and provide systematic evidence that the dysregulation of islet enhancers is relevant to the mechanisms underlying type 2 diabetes.

Type 1 diabetes is one of the most common and serious long-term diseases in children.

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T1DM used to be called childhood diabetes or insulin-dependent diabetes.

The aims of EFSD are to encourage and support groundbreaking diabetes research and to promote the next generation of leading diabetes researchers.

more Diabetologia is the Journal of the EASD and publishes original clinical, translational and experimental research within the field of diabetes.

We identify genomic sequences that are targeted by islet transcription factors to drive islet-specific gene activity and show that most such sequences reside in clusters of enhancers that form physical three-dimensional chromatin domains.

We find that sequence variants associated with type 2 diabetes and fasting glycemia are enriched in these clustered islet enhancers and identify trait-associated variants that disrupt DNA binding and islet enhancer activity.

Further, we establish a correlation between relative abundance of spp.



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